Necrosis Pancreatic Infectious Virus does not block 701-STAT1 (α/β) tyrosine in Oncorhynchus mykiss (Salmoniformes: Salmonidae).
DOI:
https://doi.org/10.22458/rc.v22i2.2788Palabras clave:
IPNV, phosphorylation, 701-Tyrosyne STAT1 (α/β), rainbow troutResumen
ABSTRACT: Necrosis Pancreatic Infectious Virus does not block 701-STAT1 (α/β) tyrosine in Oncorhynchus mykiss (Salmoniformes: Salmonidae).
Introduction: Infectious pancreatic necrosis virus (IPNV) is a pathogen important that affects predominantly salmonids. The type I interferon alpha system has a crucial role in the first line of defense against IPNV infection. IFN-I(α) activation triggers the signaling pathway JAK-STAT, binding to their receptors results in the rapid phosphorylation of STATs a critical step for the nuclear translocation to induce the interferon stimulated genes (ISGs). The relationship between infectivity level of IPNV strain and pathway signaling of IFN is yet poorly understood. Objective: our purpose was to investigate if the IFN-I(α) signaling pathway is affected by IPNV strains of different infectivity levels.
Methods: We used two IPNV isolated (VR-299 and Sp) to infect RTG-2 cells. Total RNA was isolated using the commercial kit for determine to VP2 expression and ISGs using qRT-PCR. Western Immunoblotting analysis was carried out for determine the 701 STAT1(α/β) phosphorylation into infected cells.
Results: Hence, a higher virulence strain is not associated with a greater blocking effect for interferon signaling. Furthermore, the activation of Y701-STAT1 (α/β) was significantly increased in serotype Sp virus infected cells compared with serotype VR-299 virus infected cells, indicating that IPNV inhibits IFN signaling pathway.
Conclusions: As concluded, IPNV does not block the phosphorylation of 701-tyrosine STAT1 (α/β) stimulated by IFN-I(α), contrary to other RNA viruses.
Citas
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Espinoza, J. C., Cortés-Gutierrez, M., & Kuznar, J. (2005). Necrosis of infectious pancreatic necrosis virus (IPNV) infected cells rarely is preceded by apoptosis. Virus research, 109(2), 133-138. doi: https://doi.org/10.1016/j.virusres.2004.10.014
Espinoza, J.C., Hjalmarsson, A., Everitt, E., & Kuznar, J. (2000). Temporal and subcellular localization of infectious pancreatic necrosis virus structural proteins. Archives of Virology 145(4): 739-748. doi: https://doi.org/10.1007/s007050050667
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García, I., Galiana, A., Falcó, A., Estepa, A., & Perez, L. (2011). Characterization of an infectious pancreatic necrosis (IPN) virus carrier cell culture with resistance to superinfection with heterologous viruses. Veterinary microbiology, 149(1-2), 48-55. doi: 10.1016/j.vetmic.2010.10.017.
Garcin, D., Latorre, P., & Kolakofsky, D. (1999). Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state. Journal of Virology, 73(8), 6559-6565.
Gotoh, B., Takeuchi, K., Komatsu, T., Yokoo, J., Kimura, Y., Kurotani, A., ... & Nagai, Y. (1999). Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon‐α/β‐mediated responses. FEBS letters, 459(2), 205-210. doi: 10.1016/s0014-5793(99)01241-7
Granzow, H., Weiland, F., Fichtner, D., & Enzmann, P. J. (1997). Studies of the ultrastructure and morphogenesis of fish pathogenic viruses grown in cell culture. Journal of Fish Diseases, 20(1), 1-10. doi: https://doi.org/10.1046/j.1365-2761.1997.00267.x
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Hay, S., & Kannourakis, G. (2002). A time to kill: viral manipulation of the cell death program. Journal of General Virology, 83(7), 1547-1564. doi: 10.1099/0022-1317-83-7-1547
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Hoeve, J., de Jesus Ibarra-Sanchez, M., Fu, Y., Zhu, W., Tremblay, M., David, M., & Shuai, K. (2002). Identification of a nuclear Stat1 protein tyrosine phosphatase. Molecular and cellular biology, 22(16), 5662-5668. doi: 10.1128/mcb.22.16.5662-5668.2002
Hong, J. R., Hsu, Y. L., & Wu, J. L. (1999). Infectious pancreatic necrosis virus induces apoptosis due to down-regulation of survival factor MCL-1 protein expression in a fish cell line. Virus research, 63(1-2), 75-83. doi: 10.1016/s0168-1702(99)00060-x
Horvath, C. M. (2004). Weapons of STAT destruction. European journal of biochemistry, 271(23‐24), 4621-4628. doi: https://doi.org/10.1111/j.1432-1033.2004.04425.x
International Office of Epizootics. Aquatic Animal Health Standards Commission. (2006). Manual of diagnostic tests for aquatic animals. Office International des Epizooties.
Jensen, I., & Robertsen, B. (2002). Effect of double-stranded RNA and interferon on the antiviral activity of Atlantic salmon cells against infectious salmon anemia virus and infectious pancreatic necrosis virus. Fish & shellfish immunology, 13(3), 221-241. doi: https://doi.org/10.1006/fsim.2001.0397
Jørgensen, J. B., Johansen, A., Hegseth, M. N., Zou, J., Robertsen, B., Collet, B., & Secombes, C. J. (2007). A recombinant CHSE-214 cell line expressing an Mx1 promoter–reporter system responds to both interferons type I and type II from salmonids and represents a versatile tool to study the IFN-system in teleost fish. Fish & shellfish immunology, 23(6), 1294-1303. doi: 10.1016/j.fsi.2007.07.008
Komatsu, T., Takeuchi, K., Yokoo, J., Tanaka, Y., & Gotoh, B. (2000). Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcription. Journal of virology, 74(5), 2477-2480. doi: 10.1128/JVI.74.5.2477-2480.2000
Kotenko, S. V., Gallagher, G., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., ... & Donnelly, R. P. (2003). IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex. Nature immunology, 4(1), 69. doi: 10.1038/ni875
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Publicado
2020-06-08
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Cortés, D. A. (2020). Necrosis Pancreatic Infectious Virus does not block 701-STAT1 (α/β) tyrosine in Oncorhynchus mykiss (Salmoniformes: Salmonidae). Repertorio Científico, 22(2), 1–11. https://doi.org/10.22458/rc.v22i2.2788
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