Efecto de los antibióticos en el microbioma intestinal
Palabras clave:
Antibiotico, Microbioma, AlteraciónResumen
El uso de antibióticos contribuye con la eliminación de microorganismos patógenos, sin embargo, su uso puede originar alteraciones que afectan la relación mutualista que hay entre el hospedero y la microbiota, incrementando la susceptibilidad a una enfermedad, colonización de patógenos oportunistas y derivando en una desregulación inmune.
Citas
ANTUNES, C., HAN, J., FERREIRA, R., LOLIE, P., BORCHERS, C., Y FINLAY, B. 2011. Effect of antibiotics treatment on the intestinal metabolome. Antimicrobial Agents and Chemotherapy. 55: 1494-1503.
CASH, H., WHITMAM, C., BEHRENDT, C. Y HOOPER, L. 2006. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science. 313: 1126-1130.
CHO, I. Y BLASER, M. 2012. The human microbiome: at the interface of health and disease. Nature Reviews Genetics. 13: 260-270.
DETHLEFSEN, L. Y RELMAN, D. 2010. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proceedings of the National Academy of Sciences of the United States of America.108: 4554-4561.
HILL, D., HOFFMANN, C., ABT, M., DU, Y., KOBULEY, D., KIRN, T., BUSHMAN, F. Y ARTIS, D. 2010. Metagenomic analyses reveal antibiotic-induced temporaland spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis. Nature. 3: 148-158.
JAKOBSSON, H., JERNBERG, C., ANDERSONN, A., KARLSSON, M., JANSSON,J. Y ENGSTRAND, L. 2010 Short term antibiotic treatment has differing long term impacts on the human throat ant gut microbiome. PloS ONE. 5: e 9836.
JONSSON M., QVARNSTROM Y., ENGSTRAND L. & SWEDBERG G. 2005. Clarithromycin treatment selects for persistent macrolide resistant bacteria in throat commensal flora. International Journal of Antimicrobial Agents. 25: 68-74.
KENYON, S., PIKE, K., JONES, D., BROCKLEHURST, P., NARLOW, N., SALT, A. & TAYLOR, D. 2008. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet. 372: 1319-1327.
MIYAWAKI, K., YAMADA, Y., BAN, N., IHARA, Y., TSUKIYAMA, K., ZHOU H., FUJIMOTO, S., OKU, A., TSUDA, K., TOYOKUNI, S., HIAI, H., MIZUNOYA, W., FUSHIKI, T., HOLST, J., MAKINO, M., TAHITA, A., KOBARA, Y., TSUBAMOTO, Y., JINNOUCHI, T., JOMORI, T. Y SEINO, Y. 2002. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nature Medicine. 8: 738-742.
NATHAN, C. (2004). Antibiotics at the crossroads. Nature. 431: 899-902.
RAUTAVA, S., LUOTO, R., SALMINEN, S. Y ISOLAURI, E. 2012. Microbial contact during pregnancy, intestinal colonization and human disease. Nature Gastroenterology and Hepatology. 10: 565-576.
ROBINSON, C. Y YOUNG, V. 2010. Antibiotic administration alters the community structure of the gastrointestinal microbiota. Gut Microbes. 1: 279-284.
SOBEL, J. (2007). Vulvovaginal candidosis. Lancet. 369: 1961-1971.
SOMMER, M., DANTAS, G. Y CHURCH, G. 2009. Antibiotic resistance reservoir in the human microflora. Science. 325: 1128-1131.
SCHUMANN, A., NUTTEN, S., DONNICOLA, D., COMELLI, E., MANSOURIAN, R., CHERBUT, C., CORTHESY-THEULAZ, I. Y GARCIA-RODENAS, C. 2005. Neonatal antibiotic treatment alters gastrointestinal tract developmental gene expression and intestinal barrier trascriptome. Physiological Genomics. 23: 235-245.
WILLING, B., RUSSELL, S. Y FINLAY, B. 2011. Shifting the balance: antibiotic effects on host–microbiota mutualism. Nature Microbiology. 9: 233-243.
YAP, I., LI, J., SARIC, J., MARTIN, F., DAVIES, H., WANG, Y., WILSON, I., NICHOLSON, J., UTZINGER, J., MARCHESI, J. Y HOLMES, E. 2008. Metabolomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. Journal of Proteome Research. 7: 3718-3728.
CASH, H., WHITMAM, C., BEHRENDT, C. Y HOOPER, L. 2006. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science. 313: 1126-1130.
CHO, I. Y BLASER, M. 2012. The human microbiome: at the interface of health and disease. Nature Reviews Genetics. 13: 260-270.
DETHLEFSEN, L. Y RELMAN, D. 2010. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proceedings of the National Academy of Sciences of the United States of America.108: 4554-4561.
HILL, D., HOFFMANN, C., ABT, M., DU, Y., KOBULEY, D., KIRN, T., BUSHMAN, F. Y ARTIS, D. 2010. Metagenomic analyses reveal antibiotic-induced temporaland spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis. Nature. 3: 148-158.
JAKOBSSON, H., JERNBERG, C., ANDERSONN, A., KARLSSON, M., JANSSON,J. Y ENGSTRAND, L. 2010 Short term antibiotic treatment has differing long term impacts on the human throat ant gut microbiome. PloS ONE. 5: e 9836.
JONSSON M., QVARNSTROM Y., ENGSTRAND L. & SWEDBERG G. 2005. Clarithromycin treatment selects for persistent macrolide resistant bacteria in throat commensal flora. International Journal of Antimicrobial Agents. 25: 68-74.
KENYON, S., PIKE, K., JONES, D., BROCKLEHURST, P., NARLOW, N., SALT, A. & TAYLOR, D. 2008. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet. 372: 1319-1327.
MIYAWAKI, K., YAMADA, Y., BAN, N., IHARA, Y., TSUKIYAMA, K., ZHOU H., FUJIMOTO, S., OKU, A., TSUDA, K., TOYOKUNI, S., HIAI, H., MIZUNOYA, W., FUSHIKI, T., HOLST, J., MAKINO, M., TAHITA, A., KOBARA, Y., TSUBAMOTO, Y., JINNOUCHI, T., JOMORI, T. Y SEINO, Y. 2002. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nature Medicine. 8: 738-742.
NATHAN, C. (2004). Antibiotics at the crossroads. Nature. 431: 899-902.
RAUTAVA, S., LUOTO, R., SALMINEN, S. Y ISOLAURI, E. 2012. Microbial contact during pregnancy, intestinal colonization and human disease. Nature Gastroenterology and Hepatology. 10: 565-576.
ROBINSON, C. Y YOUNG, V. 2010. Antibiotic administration alters the community structure of the gastrointestinal microbiota. Gut Microbes. 1: 279-284.
SOBEL, J. (2007). Vulvovaginal candidosis. Lancet. 369: 1961-1971.
SOMMER, M., DANTAS, G. Y CHURCH, G. 2009. Antibiotic resistance reservoir in the human microflora. Science. 325: 1128-1131.
SCHUMANN, A., NUTTEN, S., DONNICOLA, D., COMELLI, E., MANSOURIAN, R., CHERBUT, C., CORTHESY-THEULAZ, I. Y GARCIA-RODENAS, C. 2005. Neonatal antibiotic treatment alters gastrointestinal tract developmental gene expression and intestinal barrier trascriptome. Physiological Genomics. 23: 235-245.
WILLING, B., RUSSELL, S. Y FINLAY, B. 2011. Shifting the balance: antibiotic effects on host–microbiota mutualism. Nature Microbiology. 9: 233-243.
YAP, I., LI, J., SARIC, J., MARTIN, F., DAVIES, H., WANG, Y., WILSON, I., NICHOLSON, J., UTZINGER, J., MARCHESI, J. Y HOLMES, E. 2008. Metabolomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. Journal of Proteome Research. 7: 3718-3728.
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2016-06-08
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Montero García, M. . (2016). Efecto de los antibióticos en el microbioma intestinal. Repertorio Científico, 19(1), 19–25. Recuperado a partir de https://revistas.uned.ac.cr/index.php/repertorio/article/view/2530
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